Submitted by comrax on Wed, 30/01/2013 - 13:21
Prof. Aaron Ciechanover
Nobel Laureate in Chemistry, 2004
Prof. Aaron Ciechanover was awarded the Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation. He received the prize along with Prof. Avram Hershko, and his American Colleague Prof. Irwin Rose.
Prof. Ciechanover was born in 1947 in Haifa. He earned his master’s degree (1970) in science and a doctorate in medicine (1974) from the Hebrew University of Jerusalem, and an honorary doctorate from the Hebrew University (2007). He is a faculty member of the Technion-Israel Institute of Technology.
Prof. Ciechanover has made a great contribution to the understanding of the mechanism of intracellular processes. He revealed in his laboratory that the ubiquitin system, which is responsible for breaking down proteins in body cells, controls the activities of proteins that act like multiple gene “operating switches” in the cell. He revealed that this system is largely responsible for operating and halting the activities of those switches, with disruption in it potentially leading to tissue dysfunction and malignancy. In this discovery, Prof. Ciechanover provided a key to understanding the ubiquitin system and paved the way for the development of drugs to prevent and teat certain illnesses.
He serves as a distinguished research professor at the Rappaport Family Institute for Research in the Medical Sciences and as the Janet and David Polak Professor of Life Sciences at the Rappaport Faculty of Medicine at the Technion-Israel Institute of Technology.