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Algorithm leads to dramatic improvement in drug discovery methods; Prof. Amiram Goldblum wins 2017 Kaye Innovation Award

22/06/2017

An algorithm developed at the Hebrew University cuts through the immense number of possible solutions to shorten drug discovery times from years to months

Discovery earns Prof. Amiram Goldblum a 2017 Kaye Innovation Award

Antibiotics for treating particularly resistant diseases, molecules that block immune system overreactions, molecules that inhibit the growth of cancer cells by removing excess iron, molecules that may increase the digestion of fats: all these and more have been discovered in recent years using a unique computerized approach to solving particularly complex problems.

Over the past five years, an Iterative Stochastic Elimination (ISE) algorithm developed in the laboratory of Prof. Amiram Goldblum, at the Hebrew University of Jerusalem’s Institute for Drug Research, has been applied to the discovery of potential drugs. The Institute is part of the School of Pharmacy in the Faculty Of Medicine. First tested to solve problems in the structure and function of proteins, the algorithm has since been used to reduce drug discovery times — from years to months and even to weeks.

Goldblum’s solution is different from other algorithms called "heuristics," which are based on deriving solutions using logic and intuition, and suggests better solutions. In this instance, the algorithm produces a model for the activity of small molecules on one or more proteins known to cause the disease. A model is a set of filters of physico-chemical properties that distinguish between active and non-active molecules, or between more and less active ones. Millions of molecules can then be screened by the model, which enables the scoring of each molecule by a number that reflects its ability to pass through the filters based on its own physico-chemical properties.

A model of this type is usually built in a few hours and is capable of screening millions of molecules in less than a day. Therefore, within a few days or more, it is possible to make initial predictions about the candidate molecules for a specific activity to combat a disease. Most of those candidates have never been known before to have any biological activity.

For the development of this algorithm, Prof. Goldblum won an American Chemical Society Prize in 2000. Since then, the algorithm has solved many problems related to understanding various biological systems such as protein flexibility, proteins-small molecules interactions, and more. These and other discoveries stem from collaborations between Goldblum's laboratory, where his students employ the algorithm to solve various problems, and laboratories and pharmaceutical companies in the world that test Goldblum's predictions in Germany, Japan, the United States and of course in Israel.

On the strength of Goldblum’s technology, the company Pepticom was founded in 2011 by Yissum, the Technology Transfer arm of the Hebrew University, to revolutionize the discovery of novel peptide drug candidates. Pepticom’s key asset is an exceptional artificial intelligence platform aimed at designing peptide ligands based upon solved crystal structures of proteins.

Wide Applications

The algorithm can be applied to other types of problems, in which the number of possibilities is immense and are not solvable even if the world's most powerful computers would work on it together. These include problems in which the number of possible outcomes are 10 to the power of 100 and more, such as problems of land transport, aviation, communications and biological systems.

In the field of transportation, this could involve finding alternative ways to get from one point to another using traffic data on each of the alternative roads leading between the two points. In aviation, an optimal arrangement of landings and takeoffs at busy airports. In telecommunications, finding the least expensive routes within a complex array of communication cables. And in biology, a model that is constructed on the basis of a few dozen or hundreds of molecules serves to screen millions of molecules and to discover new drug candidates. These are then sent to experimental labs to be developed further, and in some cases have been crucial in furthering the development of treatment for Alzheimer’s disease and different forms of cancer.

Kaye Innovation Award

In recognition of his work, Prof. Amiram Goldblum was awarded the Kaye Innovation Award for 2017.

The Kaye Innovation Awards at the Hebrew University of Jerusalem have been awarded annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff and students of the Hebrew University to develop innovative methods and inventions with good commercial potential, which will benefit the university and society. For more information about the 2017 Kaye Innovations Awards, visit http://bit.ly/kaye2017.

About the Hebrew University of Jerusalem

The Hebrew University of Jerusalem, Israel’s leading academic and research institution, is ranked among the top 100 universities in the world. Founded in 1918 by visionaries including Albert Einstein, the Hebrew University is a pluralistic institution where science and knowledge are advanced for the benefit of humankind. For more information, please visit http://new.huji.ac.il/en

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Algorithm leads to dramatic improvement in drug discovery methods; Prof. Amiram Goldblum wins 2017 Kaye Innovation Award
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Hebrew University Launches Multidisciplinary Center on Cannabinoid Research

05/04/2017

The Hebrew University of Jerusalem has announced the launch of a Multidisciplinary Center on Cannabinoid Research (http://cannabinoids.huji.ac.il). The new Center will serve as one of the world’s leading institutes for conducting and coordinating research about cannabinoids, endocannabinoids and medical Cannabis. In addition, it will promote collaboration and disseminate information

Staffed by some of the world’s leading scientists and medical doctors from the Hebrew University and its affiliated Hadassah Medical Center, the Multidisciplinary Center is already supporting exciting new research. In February 2017, the Center awarded funding to three research projects:

"The establishment in Israel of the Multidisciplinary Center on Cannabinoid Research is of great relevance at this time since both academic institutions and pharmaceutical companies worldwide are channeling enormous efforts to basic and clinical research in this field," said Dr. Joseph (Yossi) Tam, Director of the Hebrew University’s Multidisciplinary Center on Cannabinoid Research, and Head of the Obesity and Metabolism Laboratory at the Hebrew University’s Institute for Drug Research in the Faculty of Medicine.

The Center’s research will focus on the following areas: Cancer; Pain; Inflammation & Stress Management; Immunity; Metabolism; Drug Delivery & Nanotechnology; Pharmaceutical Chemistry; Neuroscience; and Plant Science & Genetics.

Along with integrating the research activities of multiple Hebrew University research laboratories into interdisciplinary networks, the Center, which relies on the infrastructure of the Institute for Drug Research at the School of Pharmacy in the Faculty of Medicine, will also foster collaborations between its participating laboratories and other well-established research groups around the globe. 

"We feel incredibly fortunate to team up with a vast number of scientists working together on this expanding field of medicine with the significant potential to discover new therapies based on cannabinoids," said Dr. Tam.

Until very recently, the Cannabis plant and its extracts (popularly called marijuana, hashish, weed, grass, and so on) were mostly frowned upon as purely recreational drugs. However, over the last 50 years, Prof. Raphael Mechoulam at the Hebrew University has spearheaded a new scientific era of Cannabis research. Prof. Mechoulam with his colleagues isolated the active constituent of the Cannabis plant, tetrahydrocannabinol, elucidated its structure and synthesized it. Later he identified the endogenous cannabinoids (formed in the mammalian body) and thus pioneered the field of cannabinoid research.

"It has been shown that modulating endocannabinoid activity has therapeutic potential in a large number of human diseases, hence research on cannabinoids may lead to very significant advances, not only in basic science but also in therapeutics. Our Multidisciplinary Center addresses many aspects in this promising area, such as cancer, head injury, addiction, bone formation, obesity and others," said Prof. Raphael Mechoulam, Head of the Academic Committee of the Multidisciplinary Center, and the Lionel Jacobson Professor Emeritus of Medicinal Chemistry in the Hebrew University’s Faculty of Medicine.

The Center’s teams of highly qualified researchers comprise Heads of Labs and Research Groups ranging through Nano-Medicine & Nano Delivery Systems, Tumor Micro-environment, Neurobiology, Pain Relief & Plasticity, Molecular Modeling & Drug Design, Immuno-pharmacology, Free Radicals, Stress and Plant Pathogen Interactions. 

The Center’s informational resources include a World Calendar of Cannabinoids, featuring information about major upcoming events in the field of cannabinoid research.

Image for download: Hebrew University’s Multidisciplinary Center on Cannabinoid Research (Credit: Hebrew University) http://media.huji.ac.il/new/photos/hu170405_MDCR.jpg

Inquiries about the Multidisciplinary Center on Cannabinoid Research can be directed to Dr. Yossi Tam at yossit[at]ekmd.huji.ac.il.   

Hebrew University Launches Multidisciplinary Center on Cannabinoid Research
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